Endocrine Abstracts

Skeletal muscle is the principal site for insulin-stimulated glucose disposal but its ability to utilise glucose is diminished by insulin resistance associated with obesity and consequent elevations of free fatty acids (FFAs). Chronic sub-clinical inflammation, characterized by increased macrophage infiltration into obese adipose tissue is a hallmark of the insulin resistance syndrome. However, little is known about the potential role of muscle macrophages in mediating local e...